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For temporary changes when testing or debugging, setting environment variables (2) to override the compiler options is perhaps the simplest.
Once testing is finished and permanent changes are required, or if unsupported compilers are required, then copy an existing .cfg file and create your own. Any names can be used. For instance, if you wanted to have 2 configurations for the Intel compiler, one with the Intel MPI, the other with OpenMPI, then create files: x86_64-intel_impi-opt.cfg and x86_64-intel_ompi-opt.cfg and use the environment variable OIFS_COMP to switch between them. e.g. OIFS_COMP=intel_ompi (it's up to the user whether they want to create .cfg files for each build type; 'opt', 'noopt', 'nansC').
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